Description of 'dat_pk_serum_rectal_wk30_hvtn116.csv' dataset
By Lily Zhang 
April 7, 2025


STRUCTURE
1 record per participant ID, 34 participants in treatment group 1 and 2 received all 4 IV infusions.

VARIABLES
- PUB_ID: participant publication ID
- DV_serum: measured VRC01 concentrations in serum at week 30 (mcg/ml)
- SGXIGGN_Serum: IgG-normalized VRC01 concentrations in serum at week 30, dividing VRC01 concentrations in serum by IgG concentration (pg VRC01/ng IgG)
- SGXIGGN_Rectal: IgG-normalized VRC01 concentrations in rectal tissue at week 30, dividing VRC01 concentrations in rectal tissue by IgG concentrations (pg VRC01/ng IgG)
- SGXPROTN_Serum: Protein-normalized VRC01 concentrations in serum at week 30, dividing VRC01 concentrations in serum by protein concentrations (pg VRC01/ng total protein)
- SGXPROTN_Rectal: Protein-normalized VRC01 concentrations in rectal tissue at week 30, dividing VRC01 concentrations in rectal tissue by protein concentrations (pg VRC01/ng total protein)
- sex: male or female
- weight: body weight (kg)
- dose: dose level: VRC01 10 mg/kg or VRC01 30 mg/kg

Notes:
Y* = log10 DV_serum, because only this variable was also measured in AMP
Y could be log10 SGXIGGN_Rectal or log10 SGXPROTN_Rectal, both are interesting


Note from Yunda Huang 4/7/2025:
Hi Peter, for studying penetration rate across the compartments, we favored using the protein-normalized concentration given 
the flow of the antibody is less dependent on the structure. For everything else, we mostly used IgG-normalized because the 
distribution of the antibody does depend on the IgG1 structure. In your context, if I understand correctly, it seems the
IgG-normalized values are probably preferred.


We do not have IgG concentrations measured in AMP samples.
(thus SGXIGGN_Serum and SGXPROTN_Serum are not candidates for Y*)